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Warfarin's significantly less strong R-enantiomer is metabolized partially by CYP3A4 (as well as CYP1A2 and CYP2C19). Watch INR more regularly if coadministered with inhibitors of such isoenzymes and adjust warfarin dose if required.modafinil will improve the stage or influence of pantoprazole by influencing hepatic enzyme CYP2C19 metabolism. Minim